While most of the intestinal chlamydial infections are clinically quiescent, a primary chlamydia-induced enteritis has been seen under field conditions in newborn calves. Such infections may also lead to a change in the number of Escherichia coli in the GI tract, with abnormally high numbers in the abomasum and upper small intestine. Signs are more severe in colostrum-deprived calves or in those with only a partial transfer of colostral immunity. Affected newborn calves may have a transient watery to mucoid diarrhea with slight fever and nasal discharge. Many veterinary diagnostic laboratories do not routinely check diarrheic feces for chlamydiae; therefore, such an examination must be requested specifically. Treatments of choice are high doses of tetracyclines, administered parenterally or orally, or both.

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