kvazi relapsy po vysadeni CAPu

Na toto som dnes narazil na cpn help. Myslim ze je to dost podstatne info od Davida Wheldona. Pamatam si na Bandogove ukoncenie CAPu ked sa sa mu zdravotny stav po nejakom case zhorsil myslel ze je zase tam kde bol.

Doxycycline and Immunomodulation

In addition to their antimicrobial capabilities, doxycycline and minocycline are powerful immunomodulants which inhibit microglial activation in the central nervous system. They have numerous other inhibitory effects on the immune system, including downregulation of proinflammatory cytokines. This is well reviewed by Tauber and Nau: [http://www.bentham.org/cmp/samples/cmp%201-1/Nau.pdf] Doxycycline inhibits the inflammatory response to bacterial infections: [Bernardino AL, Kaushal D, Philipp MT J Infect Dis. 2009 May 1;199(9):1379-88.] Doxycycline also inhibits the action of matrix metalloproteinases.

Long term treatment of chronic C. pneumoniae infection with doxycycline is thus accompanied by an attenuation of the immune system's activity. It may be expected that withdrawal of immumodulatory antibiotics may give rise to worsening of symptoms, with flu-like symptoms and loss of energy. One may speculate that symptoms of this nature which occur within a few weeks of stopping doxycycline are due to increased destruction of dead bacterial remnants by a strengthened immune system.

Symptoms like this are unlikely to be due to regrowth of bacteria, which after all had taken years, even decades, to produce significant disease.

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